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Aflatoxin B1 from Aspergillus flavus
A6636 -
from Aspergillus flavus
DOWNLOAD MSDS (PDF)CAS Number: 1162-65-8
Empirical Formula (Hill Notation): C17H12O6
Molecular Weight: 312.27
Beilstein Registry Number: 1269174
EC Number: 214-603-3
MDL number: MFCD00869647
PubChem Substance ID: 24891116
Properties
| Related Categories | A-AM, Bioactive Small Molecules, Cancer Research, Carcinogens, Cell Biology, |
| Quality Level | PREMIUM |
| biological source | from Aspergillus flavus |
| assay | ≥98% (TLC and HPLC) |
| storage temp. | 2-8°C |
Description
Other Notes
Tandem MS data independently generated by Scripps Center for Metabolomics is available to view or download in PDF format on the Safety and Documentation tab. Tested metabolites are featured on Scripps Center for Metabolomics: METLIN Metabolite Database.
Warning
Possibly carcinogenic.
Biochem/physiol Actions
Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
Price and Availability
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Documents
Certificate of Analysis
Certificate of Origin
| A6636 - Product Information Sheet (26 KB) |
| Structure Search |  |
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Safety Information
| Symbol |   GHS06, GHS08 |
| Signal word | Danger |
| Hazard statements | H300-H310-H330-H350 |
| Precautionary statements | P201-P260-P264-P280-P284-P301 + P310 |
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 45-46-26/27/28 |
| Safety Statements | 53-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | GY1925000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Carcinogenesis and Epigenetics
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation
References
Manson MM, et al. Carcinogenesis 18, 1729-38, (1997) Abstract
Merck 14,180
Beil. 19,V,10,566
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